Activity

we compared the different grafts, key surgical steps, the advantages and disadvantages of different surgical methods to provide clinicians with new surgical insights into the treatments of IMRCT. In conclusion, IMRCT without severe glenohumeral arthritis was the best suitable indication for SCR. The clinical outcomes were positive in the short-term and middle-term following-up. More studies were necessary to determine long-term results of this surgical procedure.Transjugular intrahepatic portosystemic shunt (TIPS) is an effective treatment for portal hypertension-related complications. However, careful selection of patients is crucial. The aim of this study was to evaluate the prognostic value of serum cholinesterase (CHE) for outcomes and mortality after TIPS insertion. In this multicenter study, 389 consecutive patients with cirrhosis receiving a TIPS at Hannover Medical School, University Hospital Essen, or Medical University of Vienna were included. The Hannover cohort (n = 200) was used to initially explore the role of CHE, whereas patients from Essen and Vienna served as a validation cohort (n = 189). Median age of the patients was 58 years and median Model for End-Stage Liver Disease (MELD) score was 12. Multivariable analysis identified MELD score (hazard ratio [HR] 1.16; P less then 0.001) and CHE (HR 0.61; P = 0.008) as independent predictors for 1-year survival. Using the Youden Index, a CHE of 2.5 kU/L was identified as optimal threshold to predict postation.The generation of peptidomimetic substructures for medicinal chemistry purposes requires effective and divergent synthetic methods. We present in this work an efficient flow process that allows quick modulation of reagents for Joullié-Ugi multicomponent reaction, using spiroindolenines as core motifs. This sterically hindered imine equivalent could successfully be diversified using various isocyanides and amino acids in generally good space-time yields. A telescoped flow process combining interrupted Fischer reaction for spiroindolenine synthesis and subsequent Joulliè-Ugi-type modification resulted in product formation in very good overall yield in less than 2 hours compared to 48 hours in the batch mode. The developed protocol can be seen as a general tool for rapid and facile generation of peptidomimetic compounds. We also showcase preliminary biological assessments for the prepared compounds.The realization of large-scale H2 production from electrocatalytic water splitting is severely impeded by the kinetically sluggish and economically less viable anodic oxygen evolution reaction. Here, we establish an efficient strategy for the concurrent H2 production and oxidative alcohols refining into value-added formate by utilizing self-supported Ni2P-CoP bifunctional electrocatalysts. Benefiting from high intrinsic activity, abundant active sites, and synergistic promoting effects of bimetallic phosphides, the constructed two-electrode electrolyzer requires a cell voltage of ~ 1.3 V to achieve 10 mA cm-2 , which is more than 200 mV lower than that of pure water splitting. Moreover, simultaneous productions of H2 with near-unity conversion efficiency and formate being high faradic efficiencies of 99.8% and 89.6% oxidatively produced from methanol and glycerol, respectively, are achieved with excellent durability. This work presents a general and economic approach toward the fabrication of cost-effective electrocatalysts for the energy-efficiency and profitability requirement in large-scale renewable energy integration.Radiation therapy is one of the treatment methods for hepatocellular carcinoma. Apoptosis inhibitor However, radiation tolerance of the liver is low, and the detailed effect of radiation on liver regeneration has not been clarified. C57BL/6J mice or hepatocyte-specific p53 knockout (KO) mice (albumin [Alb]-Cre Trp53flox/flox ) were irradiated with a single fraction of 10 Gy localized to the upper abdomen. We performed 70% partial hepatectomy (PHx) 24 hours after irradiation. Liver regeneration was assessed by proliferation cell nuclear antigen (PCNA)- and Ki-67-positive hepatocyte ratios and liver-to-body weight ratio after PHx. To establish a fibrosis model, CCl4 was orally administered for 8 weeks. The murine hepatocyte cell line BNL CL.2 (CL2) was irradiated with 10 Gy. Irradiation activated p53, induced downstream p21 in the liver, and delayed liver regeneration after PHx. While PHx increased hepatocyte growth factor (HGF) levels and activated Met with or without irradiation in the regenerative liver, it activated Akt and extracellular kinase 1 and 2 (Erk 1/2) less in irradiated mice than in nonirradiated mice. In CL2 cells cultured with HGF, irradiation suppressed cell growth by decreasing phosphorylated Akt and Erk 1/2 levels, which was abolished by small interfering RNA-mediated p53 knockdown but not by p21 knockdown. Hepatocyte-specific knockout of p53 in mice abolished the irradiation-induced suppression of both liver regeneration and Akt and Erk 1/2 activation after PHx. In the fibrotic mouse model, the survival rate after PHx of irradiated p53 KO mice was higher than that of wild-type mice. Conclusion p53 but not p21 is involved in the impaired regenerative ability of the irradiated liver.

The association between physical activity and adiposity in preschool-aged children is unclear.

To assess the cross-sectional association between objectively measured physical activity and body fat in preschool-aged children.

In the preschool review in an Australian birth cohort study (n=1074), mean duration and time accumulated in ≥1-min bouts of physical activity at light-intensity (LPA), moderate- to vigorous-intensity (MVPA) and light- to vigorous-intensity (LMVPA) were computed from accelerometer (ActiGraph GT3X+) data. Percent body fat was assessed by bioelectrical impedance. Associations between physical activity and percent body fat were examined by multiple regression, adjusted for accelerometer wear time, MVPA (in analyses of LPA), maternal body mass index (BMI) and maternal education.

A total of 450 participants (n=450) had valid data. There was evidence of associations between physical activity and adiposity each additional hour of LVPA was associated with 0.6% (CI

-0.2%, 1.3%) higher body fat; ≥1-min bouts of LPA was associated with 1.0% (CI

0.1%, 1.9%) higher body fat; each additional hour of MVPA was associated with -0.8% (CI

-1.6%, -0.1%) less body fat; and ≥1-min bouts of MVPA was associated with -1.3% (CI

-2.5%, -0.1%) body fat.

Among a cohort of preschool-aged children, there was evidence that more intensive physical activity assessed by an accelerometer is associated with reduced body fat.

Among a cohort of preschool-aged children, there was evidence that more intensive physical activity assessed by an accelerometer is associated with reduced body fat.

Predicting the risk of malignant arrhythmias (MA) in hospitalized patients with heart failure (HF) is challenging. Machine learning (ML) can handle a large volume of complex data more effectively than traditional statistical methods. This study explored the feasibility of ML methods for predicting the risk of MA in hospitalized HF patients.

We evaluated the baseline data and MA events of 2794 hospitalized HF patients in the HF cohort in Anhui Province and randomly divided the study population into training and validation sets in a 73 ratio. The Lasso-logistic regression, multivariate adaptive regression splines (MARS), classification and regression tree (CART), random forest (RF), and eXtreme gradient boosting (XGBoost) algorithms were used to construct risk prediction models in the training set, and model performance was verified in the validation set. The area under the receiver operating characteristic curve (AUC) and Brier score were employed to evaluate the discrimination and calibration of the model. Oral antiarrhythmic drug, left bundle branch block, serum magnesium, d-dimer, and random blood glucose were significant predictors in half or more of the models.

The current study findings suggest that ML models based on the Lasso-logistic regression, MARS, RF, and XGBoost algorithms can effectively predict the risk of MA in hospitalized HF patients. The Lasso-logistic model had better clinical interpretability and ease of use than the other models.

The current study findings suggest that ML models based on the Lasso-logistic regression, MARS, RF, and XGBoost algorithms can effectively predict the risk of MA in hospitalized HF patients. The Lasso-logistic model had better clinical interpretability and ease of use than the other models.Streptococcus equi subsp. zooepidemicus (SEZ) is a highly contagious infectious organism that causes disease in horses. SEZ is seldom isolated from humans; however, zoonotic infections are occasionally reported in individuals exposed to horses and other livestock. Herein, we report three human cases of SEZ in individuals, one with direct horse contact and two among individuals who had eaten raw horse meat. The phylogenetic tree showed that the genotypes of SEZ isolates from two of the cases on Jeju Island, South Korea, were similar to those of isolates from the United Kingdom and the United States of America.This analysis was conducted to assess exposure-response relationships for efficacy and safety of pexidartinib in patients with tenosynovial giant cell tumor. Efficacy was assessed categorically by overall response rate (ORR) with Response Evaluation Criteria in Solid Tumors version 1.1 and longitudinally (changes in tumor size and volume). Safety included hepatic parameters (i.e., alanine aminotransferase [ALT], aspartate aminotransferase [AST], and total bilirubin). Average pexidartinib concentration (Cavg ) was identified as the primary exposure parameter correlated with response. In categorical and longitudinal analyses, higher Cavg coincided with greater ORR and tumor size reduction, respectively, with smaller joint size having a greater impact. For safety, a significant relationship was observed between Cavg and incidence of ALT-related and AST-related adverse events (AEs). With increased exposure, an increase in efficacy was predicted with near maximum effect at 800 mg/day. Higher initial dose (1000 mg/day) during the first 2 weeks did not improve efficacy. Higher doses were associated with an increased risk of ALT-related and AST-related AEs. These results support the US Food and Drug Administration-approved dose (400 mg two times/day without initial loading dose).

Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify the contribution of liver and gut microbiota to BA metabolism disturbance in cancer cachexia and to check the possibility of targeting BA metabolism using agents such as tauroursodeoxycholic acid (TUDCA) for cancer cachexia therapy.

The BA profiles in liver, intestine, and serum of mice with cancer cachexia induced by inoculation of colon C26 tumour cells were analysed using metabolomics methods and compared with that of control mice. Proteomic analysis of liver protein expression profile and 16S rRNA gene sequencing analysis of gut microbiota composition in cancer cachexia mice were conducted. Expression levels of genes related to farnesoid X receptor (FXR) signalling pathway in the intestine and liver tissues were analysed using RT-PCR analysis. The BA profiles in serum of clinical colon cancer patients with or without cachexia were also analysed and compared with that of healthy volunteers.