Activity

. The difference in the stimulation montages and parameters, diverse cognitive batteries, and variable number of training sessions may have contributed to the inconsistency in the outcome. We suggest that in future studies, experimental designs should be further refined, and standardized stimulation protocols should be utilized to better understand the therapeutic effect of stimulation.

The results favor the efficacy of tES in an improvement in aphasia and attentive deficits in stroke patients in acute, subacute, and chronic stages. However, the outcome of tES cannot be generalized across cognitive domains. The difference in the stimulation montages and parameters, diverse cognitive batteries, and variable number of training sessions may have contributed to the inconsistency in the outcome. We suggest that in future studies, experimental designs should be further refined, and standardized stimulation protocols should be utilized to better understand the therapeutic effect of stimulation.

There are many different Thoracic Lumbar Sacral Orthosis style brace designs available in the market for the correction of scoliosis deformity. Hole cut out patterns, are commonly used in brace designs. These cut-outs may be subdivided into two groups hole patterns and windows. Hole patterns are an array of holes which are implemented to lighten the weight of a brace and allow for the skin to breathe. Windows provide space for spinal derotation and/or breathing. From an examination of the literature, it appears that a systematic analysis of the effect of these cut-outs on the structural integrity and functionality of the brace has not been undertaken. Furthermore, there is a lack of understanding on the effect of spacing, size and geometry of the cut-outs on the mechanical behavior of the brace.

In this study, Finite Element Analysis is employed to examine the mechanical response of the brace to these cut-outs. Geometry for the Thoracic Lumbar Sacral Orthosis was obtained by scanning an existing brace usiuts does not affect the brace stress and deformation significantly. TIC10 Thus, the size of these windows should be based on the functional aspects of the brace, i.e., the minimum required size needed to permit the patient to breathe comfortably as in the case of the abdominal window or to allow for proper derotation, as in the case of the derotation window.

To conduct a systematic review and meta-analysis of available studies regarding the effects of the traditional herb

(as topical application and oral intake) on the severity of acute pain in adults.

A systematic search was performed on the following databases Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science Core Collection, Embase, Cumulative Index to Nursing and Allied Health Literature, Scientific Information Database, and Magiran from inception to 20 March 2021. We included parallel-group and cross-over randomized controlled trials that compared the effects of any products containing

in oral and topical administration forms to placebo, non-treatment, or conventional treatment. Two researchers independently performed the document screening and selection, data extraction, and risk of bias assessment. A random-effect model was used to pool the data.

From a total of 11 studies that met the inclusion criteria, four studies administered

through topical application and ain in adults.

This systematic review and meta-analysis suggests that the oral intake of R damascena may have a non-significant alleviating effect on acute pain severity in adults. However, its topical application has not shown pain-alleviating effect. More robust randomized controlled trials are needed for accurate estimation of the effects of oral and topical use of R damascena on the severity of different types of acute pain in adults.Tracheobronchial mucoepidermoid tumors (METs) typically occur in the head and neck region but rarely in the trachea and lung. They are salivary-type tumors that arise from the glandular component of the tracheobronchial epithelium. The most common type, mucoepidermoid carcinoma (MEC) has histological features that overlap with more aggressive lung carcinomas such as adenosquamous carcinoma. It is important to realize the histological features and limitations of a diagnostic biopsy. This case illustrates this point where an initially diagnosed lung adenocarcinoma turns out to be MEC. We report a case of a 43-year-old woman with a one-year history of recurrent episodes of cough and fever. Initial bronchial biopsy diagnosed her as having adenocarcinoma of the lung. However, her surgical biopsy confirmed it was MEC. High clinical suspicion that the diagnosis may not have been correct saved her from a potential pneumonectomy. She instead underwent bi-lobectomy sleeve resection. This case illustrates the importance of recognizing less common and less aggressive lung tumors that may appear histologically as adenosquamous carcinoma. High clinical suspicion, not only biopsy results, from clinical history, imaging and gross appearance is always needed in all cases. The use of intraoperative frozen section is mandatory. It is important to be aware that because of morphological limitations of small endobronchial biopsies, diagnosis of a more common pathology may be favored.

Alopecia areata (AA) is a multifactorial autoimmune disease with a strong genetic predisposition. A variety of genes involved in immunity and inflammatory responses, such as cytokines, are suspected to increase the risk of developing AA. In which, different interleukin (IL) genes that associated with several autoimmune diseases and AA in varied populations. The objective of this study was to investigate the possible genetic association of AA with ten variants of single nucleotide polymorphism (SNP) in

and

genes among Jordanian patients.

In this case-control study, peripheral blood samples of 152 Jordanian AA patients and 150 controls (total of 302 subjects) were collected, genomic DNA extracted and genotyped, based on which their allele and genotype frequencies were assessed.

In the rs11073001 SNP located in the exon region of the

gene, the A allele was distributed more frequently in AA patients (

0.01). A difference was found between the patients and the controls for the rs17875491 SNP in the promoter region of the

gene (

0.04). The mean age of onset was 27.3±12.6 with male predominance. Most patients (68.4%) were asymptomatic but some reported experiencing associated sensations before the hair loss episodes. The patchy patterns of alopecia were the most common (90.3%). Nail changes were found in 7.3% of the patients.

The findings support the hypothesis of the involvement of

gene in the etiology of AA. Moreover, it emphasizes the variations in the genetic component of AA, as well as the clinical phenotypes among different ethnic groups.

The findings support the hypothesis of the involvement of IL16 gene in the etiology of AA. Moreover, it emphasizes the variations in the genetic component of AA, as well as the clinical phenotypes among different ethnic groups.

To establish a reference range for acylcarnitines (ACs) and amino acids (AAs) concentrations in dried blood spot (DBS) samples of Omani neonates to detect inborn errors of metabolism (IEM), and to evaluate the effect of age and sex on ACs and AAs.

Electrospray-ionization tandem mass spectrometry (+ESI-MS/MS) was used to determine ACs and AAs concentrations in DBS samples collected from 1302 healthy newborns (0-7 days) delivered at Sultan Qaboos University Hospital between August 2008 and May 2009.

More than fifty biomarkers that allow diagnosis of various IEMs were measured, their 1

and 99

percentile values determined, and compared with published international data. Our results were comparable with the corresponding figures from Collaborative Laboratory Integrated Report, despite a much smaller sample size. We found that age had a significant effect on most ACs and AAs except decadienoylcarnitin, decenoylcarnitine, adipylcarnitine, palmitoylcarnitine, steatoylcarnitine, tyrosin, phenylalanine, and valine. Sex of the neonate had insignificant effect on most ACs and AAs except free-carnitine, acetylcarnitine, hexanoylcarnitine, octanoylcarnitine, malonylcarnitine, decanoylcarnitine, dodecenoylcarnitine, dodecanoylcarnitine, and tetradecanoylcarnitine.

Tandem mass spectrometer is a highly effective tool for high throughput screening of IEM. This study is the first to publish reference intervals for ACs and AAs from DBS samples of Omani newborns. The results may prove to be of significance when determining cut-off values for newborn screening in the near future.

Tandem mass spectrometer is a highly effective tool for high throughput screening of IEM. This study is the first to publish reference intervals for ACs and AAs from DBS samples of Omani newborns. The results may prove to be of significance when determining cut-off values for newborn screening in the near future.Individuals born with trisomy 13 tend to be susceptible to Meckel’s diverticulum. It is rarely symptomatic and reported cases are extremely rare. We describe here a neonate with feeding intolerance and bilious aspirates as a result of Meckel’s diverticulum and peritoneal band which caused intermittent volvulus with obstruction.

We sought to evaluate the incidence of 28-day hospital readmission in a tertiary hospital in Oman and identify potential factors associated with increased risk of hospital readmission.

We conducted a retrospective study of all adult patients (≥ 18 years) admitted under the care of the General Internal Medicine unit from 1 June to 31 December 2020 at Sultan Qaboos University Hospital. Elective admissions and COVID-19 infection-related admission were excluded from the study.

There were 200 patients admitted during the study period. The mean age was 58.6±19.3 years, and 106 (53.0%) patients were males. Forty-eight (24.0%) patients had unplanned readmission within 28-days after discharge from the hospital. Patients with 28 days unplanned readmission were older (66.6 vs. 56.0 years,

< 0.001) and had a longer length of hospital stay (6.0 vs. 4.0 days,

< 0.001). Also, hypertension (77.1% vs. 55.3%,

0.007), diabetes mellitus (64.6% vs. 48.0%,

0.045), and comorbidity (≥ 3 comorbidities, [43.8% vs. 23.8%,

0.005]) were more prevalent in the unplanned readmission group. Patients with poor functional status (43.7% vs. 26.3%,

< 0.001), requiring feeding tube (25.0% vs. 5.3%,

< 0.001), and with polypharmacy (75.0% vs. 50.0%,

0.003) were at increased risk of readmission.

28-day hospital readmission is prevalent in our health care setting. Old age, polypharmacy, comorbidities, and poor functional status were associated with an increased risk of hospital readmission. Therefore, evidence-based interventions must be implemented in our health care system to minimize the risk of hospital readmission.

28-day hospital readmission is prevalent in our health care setting. Old age, polypharmacy, comorbidities, and poor functional status were associated with an increased risk of hospital readmission. Therefore, evidence-based interventions must be implemented in our health care system to minimize the risk of hospital readmission.