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    Over the last few years, a number of metabolic precursors to either testosterone or nandrolone have been marketed as dietary supplements in the U.S., and while their efficacy in lowering the incidence or reducing the severity of erectile dysfunction has been demonstrated, whether they actually improve sexual function remains unknown.

    In the current study at UCLA, the researchers determined the concentrations of metabolites and hormones in ejaculated semen using gas chromatography mass spectrometry. The researchers also determined the testosterone content and distribution in semen samples from 12 healthy men, ages 22 to 38 years, who were not receiving treatment for erectile dysfunction and who had already been treated for a lower testosterone level.

    Overall testosterone levels in semen from the 12 men ranged from 20.3ng/ml to 32.0ng/ml. Compared with the total testosterone content of the men’s bodies, there was a lower concentration of total testosterone in ejaculated semen of men who’d suffered an anabolic period of at least three months.

    The men’s baseline testosterone concentration also declined with an anabolic period of at least three months. The most dramatic decrease in total testosterone concentration occurred between the third and fourth ejaculatory weeks, when anabolic activity had decreased, and during the most intense stimulation of the muscles. There was also a decrease with anabolic activity associated with a decline in the number of spermatozoa in ejaculated semen. But when there was no anabolic period, total testosterone levels remained constant, and that was true even for men with no significant anabolic action during their erections.

    “What the study shows is that, while the seminal plasma has some anabolic activity that increases testosterone concentrations, it may not be enough to improve sexual function or help people avoid an anabolic phase,” says study co-author Robert Miller, a professor of obstetrics and gynecology at UCLA. “This suggests that there are other ways that testosterone can be used to stimulate libido or sexual desire, and the fact that it is so easily metabolized has helped researchers figure them out. Our next steps are to test and characterize these other options.”

    For the study, the researchers treated all 16 men for five weeks with three types of anabolic steroids (diphenhydramine, anabolics and oxandrolone) combined with another four-week anabolic protocol that the men chose or not. The first two treatments involved using two types of steroids combined, the third treatment involved taking anabolics together with the three steroids, and the final treatment involved taking oxandrolone alone with both anabolics and oxandrolone. Each individual treatment lasted two weeks.

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